Dual Photoredox and Nickel Catalysed Reductive Coupling of Alkynes and Aldehydes

A regioselective vinylation of aromatic and aliphatic aldehydes promoted by the merging photoredox nickel catalysis is here reported. comprehensive investigation on reaction conditions allowed disclosure a valid reproducible protocol based nickel-mediated reductive coupling approach under visible light irradiation. The employment 3CzClIPN (2,4,6-tris(carbazol-9-yl)-5-chloro-isophthalonitrile) as photocatalyst Hantzsch's ester sacrificial organic reductant replace use boron-, silicon- or zinc-based reducing agents, making this method worthy alternative to already known protocols. developed mild allow access wide range substituents decorating both aldehyde alkyne. Moreover, careful photophysical investigations shed mechanism reaction.